People using Mangochi-Liwonde road were stuck as minibus drivers and conductors put up 'roadblocks' along the way.
According to one of the drivers the closing of the roads was due to the increment in fuel prices.
"They have increased our tax, we are paying the tax of 16 people instead of 8, this is really killing us," he said.
Some passengers also expressed worry over the strike saying it was delaying them.
The protests started in the wee hours of Monday, in Mangochi at forest.
There were running battle between police, minibus drivers and conductors.
Police has since used teargas to disperse them.